2014

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Wheat has been shown to play a major role in the development in noth animal models and T1D in humans.

Adlercreutz EH1, Weile C, Larsen J, Engkilde K, Agardh D, Buschard K, Antvorskov JC. A gluten-free diet lowers NKG2D and ligand expression in BALB/c and non-obese diabetic (NOD) mice. Clin Exp Immunol. 2014 Aug;177(2):391-403.

Adlercreutz EH, Svensson J, Hansen D, Buschard K, Lernmark A, Mortensen HB, Agardh D. Prevalence of celiac disease autoimmunity in children with type 1 diabetes: regional variations across the Øresund strait between Denmark and southernmost Sweden. Pediatr Diabetes. 2014 Aug 18.

Larsen J, Dall M, Antvorskov JC, Weile C, Engkilde K, Josefsen K, Buschard K. Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion. Eur J Immunol. 2014 Oct;44(10):3056-67.

Hansen CH, Andersen LS, Krych L, Metzdorff SB, Hasselby JP, Skov S, Nielsen DS, Buschard K, Hansen LH, Hansen AK. Mode of delivery shapes gut colonization pattern and modulates regulatory immunity in mice. J Immunol. 2014 Aug 1;193(3):1213-22.

Antvorskov JC, Josefsen K, Engkilde K, Funda DP, Buschard K. Dietary gluten and the development of type 1 diabetes. Diabetologia. 2014 Sep;57(9):1770-80.

Nielsen DS, Krych L, Buschard K, Hansen CH, Hansen AK. Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS Lett. 2014 Apr 18

Funda DP, Fundova P, Hansen AK, Buschard K. Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice. PLoS One. 2014 Apr 11;9(4):e94530.

Hansen CH, Krych L, Buschard K, Metzdorff SB, Nellemann C, Hansen LH, Nielsen DS, Frøkiær H, Skov S, Hansen AK. A maternal gluten-free diet reduces inflammation and diabetes incidence in the offspring of NOD mice. Diabetes. 2014 Aug;63(8):2821-32.

Pyndt Jørgensen B, Hansen JT, Krych L, Larsen C, Klein AB, Nielsen DS, Josefsen K, Hansen AK, Sørensen DB. A possible link between food and mood: dietary impact on gut microbiota and behavior in BALB/c mice. PLoS One. 2014 Aug 18;9(8):e103398.

Sørensen JO, Buschard K, Brogren CH: The preventive role of type 2 NKT cells in the development of type 1 diabetes. APMIS 122: 167-182. 2014.

Svalgaard JD, Særmark C, Dall M, Buschard K, Johansen JD, Engkilde K: Systemic immunogenicity of para-phenylenediamine and diphenylcyclopropenone: two potent contact allergy-inducing haptens. Immunol Res. 58: 40-50, 2014.

Adlercreutz EH, Hansen D, Mortensen HB, Lernmark Å, Buschard K, Agardh D, Svensson J: Risk of celiac disease autoimmunity is modified by non-HLA genetic markers during the first year of clinical type 1 diabetes. J Diabetes Endocrinology. 2: 58-64, 2014.

Theses

Emma Adlercreutz: The Perfect Storm? Gluten and type 1 diabetes. Med.dr. thesis.

Jesper Larsen: NK cells and gliadin in the development of type 1 diabetes. PhD thesis.

Mia Kolbjørn Melgaard: 2′,5′-oligoadenylate synthetase activity in beta-cells and beta-cell lines, measured by fluorometry and separation by thin layer chromatography. Master thesis.

Noor Al-Shamary: Noninvasive Imaging of the pancreatic beta-cell mass using fragments and engineered formats of the monoclonal autoantibody, IC2 – Comparative studies by Near-Infrared and Positron Emission Tomography Imaging. Master Thesis.

Amila Kapicic: Identification and characterization of the monoclonal IC2 autoantibody targeted plasma membrane lipids by hyphenated HPTLC DESI-Mass Spectrometry. Master thesis.

Christina Petersen Engmose: The role of immune regulatory NKT cells in T1D and their inhibition by the monoclonal autoantibody IC2. Master thesis. Submitted.

Signe Marie Borch Nielsen: Aspects of hepatic metabolic dysfunction in Huntington´s disease. PhD thesis. Submitted.